Triptigab
TRIPTIGAB™ is a dual-action formulation combining Gabapentin and Nortriptyline for the effective management of neuropathic pain. The combination targets multiple pain pathways, providing enhanced relief from chronic neuropathic symptoms while improving patient comfort and quality of life. Gabapentin modulates neuronal calcium channels, reducing the release of excitatory neurotransmitters involved in pain transmission. Nortriptyline, a tricyclic antidepressant, enhances descending inhibitory pain pathways through modulation of norepinephrine and serotonin activity.
Neuropathic pain is a common yet under-recognized complication in patients with Chronic Kidney Disease (CKD), particularly those with diabetic kidney disease, uremic neuropathy, and dialysis-related nerve dysfunction. TRIPTIGAB™ helps address symptoms such as burning sensation, tingling, numbness, electric shock-like pain, hyperalgesia, and sleep disturbances associated with neuropathy.
The low-dose combination offers synergistic pain control, allowing effective symptom management with improved tolerability and reduced pill burden.
Category: Pain Management
Composition
Each film-coated tablet contains:
- Gabapentin IP – 100 mg
- Nortriptyline Hydrochloride IP – 10 mg
Indications
TRIPTIGAB™ is indicated for the management of:
- Peripheral neuropathic pain
- Diabetic peripheral neuropathy
- Neuropathic pain associated with Chronic Kidney Disease (CKD)
- Uremic neuropathy
- Post-herpetic neuralgia
- Radiculopathy and nerve compression syndromes
- Chronic mixed neuropathic pain conditions
- Neuropathic pain associated with dialysis patients
- Burning feet syndrome and paresthesias
Dosage
As directed by the physician.
Dose adjustment may be required in patients with renal impairment depending upon the degree of kidney dysfunction and clinical response.
How Pregabalin + Nortriptyline works
Pregabalin + Nortriptyline is a combination of two medicines: Pregabalin and Nortriptyline. Pregabalin is an alpha 2 delta ligand which decreases the pain by modulating calcium channel activity of the nerve cells. Nortriptyline is a tricyclic antidepressant which increases the levels of chemical messengers (serotonin and noradrenaline) that stop the movement of pain signals in the brain. Together, they relieve neuropathic pain (pain from damaged nerves).
Uses of Pregabalin And Nortriptyline Tablets
Pregabalin And Nortriptyline Tablets are used to treat pain that arises from nerve damage in diabetes. This medication is an effective treatment for spinal cord recovery. Below are some of the conditions that are cured using pregabalin and nortriptyline tablets.
- Shingles infection
- Diabetic nerve damage
- Fibromyalgia
- Pain Relief
- Depression’
Directions for Use
Follow the given directions before taking this tablet medication.
- Wash your hands
- Swallow the tablets gently with lukewarm water
- Do not crush or chew the tablets
Side Effects Of Pregabalin And Nortriptyline Tablets
Pregabalin and Nortriptyline Tablets may cause some side effects which need some attention. Talk to the doctor if any of the symptoms become worse and do not neglect that symptom.
- Flatulence
- Headache
- Nausea
- Stomach pain
- Vomiting
- Dizziness
Precautions For Pregabalin And Nortriptyline Tablets
Pregabalin and Nortriptyline Tablets should be taken at night or before going to bed as it is neuro medicine that causes dizziness and sleepiness. Taking it at night prevents sleepiness throughout the day. Talk to the doctor if the patient has any internal organ issues.
- Allergies
- Liver problems
- Kidney problems
- Pregnancy and Breastfeeding
- Alcohol usage
Dose: As directed by your healthcare professional.
Disclaimer
This information is for registered medical practitioner only. All others should consult a medical practitioner before using it
